Nature, Published online: 10 June 2026; doi:10. 1038/s41586-026-10633-1 Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.
Source: [Nature](https://www.nature.com/articles/s41586-026-10633-1)