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RNA therapeutics have emerged as one of the most promising new classes of medicines. Eight small interfering RNA (siRNA) drugs have already been approved worldwide for the treatment of genetic diseases, yet scientists have not fully understood one of the most fundamental steps underlying their f...
Nature, Published online: 10 June 2026; doi:10. 1038/s41586-026-10640-2 Structures of the AGO maturation complex reveal how chaperones and an RNA duplex drive assembly of the RNA-induced silencing complex.
Proteins are how cells get work done. They carry out nearly every important cellular task, from ferrying messages to controlling which genes are turned on or off. And in order for proteins to perform their various roles, the strings of amino acids that make them up need to be folded into the co...
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